منابع مشابه
Leptin and reproduction.
Leptin, a hormone secreted from adipose tissue, plays an important role in reproductive physiology. It has been shown to stimulate the reproductive system by rescuing the sterility of leptin-deficient mice and advancing the onset of puberty in normal mice. Although leptin is not critical for the biology of pregnancy in mice, its ability to reduce food intake is blunted in mid-gestation suggesti...
متن کاملLeptin and reproduction.
Fertility in mammals requires adequate nutrition and a certain reserve of metabolic fuel (Van Der Spuy, 1985). Individuals experiencing wasting diseases (e.g. insulin-dependent diabetes), severe dietary restriction (e.g. anorexics), or who are high-performance athletes (e.g. marathon runners or ballet dancers) may have severely impaired reproductive systems (De Souza & Metzger, 1991; Stewart, 1...
متن کاملLeptin in reproduction.
PURPOSE OF REVIEW Leptin, a key hormone in energy homeostasis and neuroendocrine function, has a permissive role in initiating puberty and is crucial in the pathogenesis of reproductive dysfunction in several disease states of energy imbalance. KiSS1 neurons have recently been suggested to mediate leptin's effect on the reproductive system. New insights from recent animal studies and clinical t...
متن کاملLeptin, nutrition and reproduction: new insights.
Recent data suggest that in addition to leptin's role in conveying signals of the amount of energy stores to the central nervous system, this adipocyte secreted hormone interacts with the endocrine system to provide critical information about the size of fat stores, acting as a permissive factor that allows the triggering of energy demanding situations as the onset of puberty and reproduction. ...
متن کاملRole of leptin in female reproduction.
Reproductive function is dependent on energy resources. The role of weight, body composition, fat distribution and the effect of diet have been largely investigated in experimental female animals as well as in women. Any alteration in diet and/or weight may induce abnormalities in timing of sexual maturation and fertility. However, the cellular mechanisms involved in the fine coordination of en...
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ژورنال
عنوان ژورنال: Proceedings of the Nutrition Society
سال: 1998
ISSN: 0029-6651,1475-2719
DOI: 10.1079/pns19980061